Article
Neurodevelopmental effects of the FMR-1 full mutation in humans.
Nature medicine - 1 Feb 1995
Reiss A L, Abrams M T, Greenlaw R, Freund L, Denckla M B
Abstract excerpt
Brain dysfunction is the most important sequelae of the fragile X (FMR-1) mutation, the most common heritable cause of developmental disability. Using magnetic resonance imaging (MRI) and quantitative morphometry, we have compared the neuroanatomy of 51 individuals with an FMR-1 mutation with matched controls and showed that subjects with an FMR-1 mutation have increased volume of the caudate nucleus and, in...
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