Article
Neurodevelopmental effects of the FMR-1 full mutation in humans.
Nature medicine - 1 Feb 1995
Reiss A L, Abrams M T, Greenlaw R, Freund L, Denckla M B
Abstract excerpt
Brain dysfunction is the most important sequelae of the fragile X (FMR-1) mutation, the most common heritable cause of developmental disability. Using magnetic resonance imaging (MRI) and quantitative morphometry, we have compared the neuroanatomy of 51 individuals with an FMR-1 mutation with mat...
Topics
- Adolescent
- Adult
- Age Factors
- Brain
- Child
- Child, Preschool
- DNA
- Diseases in Twins
- Female
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Humans
- Intellectual Disability
- Intelligence
- Magnetic Resonance Imaging
- Male
- Matched-Pair Analysis
- Methylation