Article
Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation.
Biological psychiatry - 1 Nov 2011
Hessl David, Wang John M, Schneider Andrea, Koldewyn Kami, Le Lien, Iwahashi Christine, Cheung Katherine, Tassone Flora, Hagerman Paul J, Rivera Susan M
Abstract excerpt
BACKGROUND: The fragile X premutation provides a unique opportunity for the study of genetic and brain mechanisms of behavior and cognition in the context of neurodevelopment and neurodegeneration. Although the neurodegenerative phenotype, fragile X-associated tremor/ataxia syndrome, is well described, evidence of a causal link between the premutation and psychiatric disorder earlier in life, clear delineation of...
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