A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: evidence from 15,857 subjects.

doi:10.1016/j.lungcan.2008.12.009

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Article

A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: evidence from 15,857 subjects.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2009

Li Yan, Qiu Li-Xin, Shen Xiao-Kun, Lv Xiao-Jing, Qian Xiao-Ping, Song Yong

Abstract excerpt

The genetic polymorphism of TP53 codon 72 is thought to have significant effect on lung cancer risk, but the results are inconsistent. In this meta-analysis, we assessed 23 published studies involving 15,857 subjects of the association between TP53 codon 72 polymorphism and risk of lung cancer. For the homozygote Pro/Pro and Pro allele carriers (Pro/Pro+Pro/Arg), the ORs for all studies combined (7495 cases and...

Topics

Asian People
Codon
Gene Frequency
Genes, p53
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Polymorphism, Single Nucleotide
Proline
Smoking
White People

Source

Open in PubMed

Identifiers

PMID: 19178978
DOI: 10.1016/j.lungcan.2008.12.009

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