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DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer

24 Nov 2020

Abstract excerpt

Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fork organization. The principal idea of participation of different polymerases in specific transactions at the fork...

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PMID: 33255191
DOI: 10.3390/cancers12123489

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