Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.

The Journal of biological chemistry - 14 Dec 2007

Abhyankar Mayuresh M, Urekar Craig, Reddi Prabhakara P

Abstract excerpt

Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. How these genes remain silent in the somatic tissues is not well understood. Our previous studies using the round spermatid-specific mouse SP-10 gene, which codes for an acrosomal protein, revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Enhancer Elements, Genetic

Share to Gene Silencing

Share to Organ Specificity

Share to Spermatids

Share to Testis

Source

Identifiers

PMID: 17932037
DOI: 10.1074/jbc.M705811200

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.PMID 17932037Read ↗

TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.Semantic proximity Read ↗

Round Spermatid-Specific Transcription of the Mouse SP-10 Gene Is Mediated by a 294-Base Pair Proximal Promoter1Semantic proximity Read ↗

A 50-bp enhancer of the mouse acrosomal vesicle protein 1 gene activates round spermatid-specific transcription in vivo†Semantic proximity Read ↗

Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.Semantic proximity Read ↗

Heat stress induced piRNA alterations in pachytene spermatocytes and round spermatidsSemantic proximity Read ↗

Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein.Semantic proximity Read ↗

A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongationSemantic proximity Read ↗

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.Semantic proximity Read ↗

High accumulation of components of the RNA polymerase II transcription machinery in rodent spermatidsSemantic proximity Read ↗

Sp1 and Egr1 Regulate Transcription of the Dmrt1 Gene in Sertoli Cells1Semantic proximity Read ↗

Immortalization and characterization of a Sertoli cell line from the adult rat.Semantic proximity Read ↗

Expression pattern, subcellular localization and structure–function relationship of rat Tpx‐1, a spermatogenic cell adhesion molecule responsible for association with Sertoli cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.