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Article

Immortalization and characterization of a Sertoli cell line from the adult rat.

Biology of reproduction - 1 Dec 1995

Roberts K P, Banerjee P P, Tindall J W, Zirkin B R

Abstract excerpt

To facilitate investigations of the regulation of adult Sertoli cell function, we have established a Sertoli cell line from sexually mature Sprague-Dawley rats. The cells were immortalized with the temperature-sensitive mutant of the SV40 virus, tsA255. The tsA255 large T antigen is heat-labile and efficiently promotes propagation of cells at 33 degrees C (permissive temperature) but is inactive at 40 degrees C...

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Identifiers

PMID: 8562702
DOI: 10.1095/biolreprod53.6.1446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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