Modulation of beta-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53.

doi:10.1002/pros.20660

Article

Modulation of beta-catenin-mediated TCF-signalling in prostate cancer cell lines by wild-type and mutant p53.

The Prostate - 1 Dec 2007

Prowald Alexandra, Cronauer Marcus V, von Klot Christoph, Eilers Tyark, Rinnab Ludwig, Herrmann Thomas, Spindler Klaus-Dieter, Montenarh Mathias, Jonas Udo, Burchardt Martin

Abstract excerpt

BACKGROUND: Deregulation of the canonical Wnt/beta-catenin-pathway is known to play an important role in the progression of various tumour cell types including prostate cancer (PCa). Recently, the tumour-suppressor p53 was shown to down-regulate beta-catenin-signalling in colon cancer. As p53 is frequently mutated in late stage PCa we investigated the effect of wild-type p53 (p53wt) as well as p53-mutants on...

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