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Article

Down-regulation of beta-catenin by activated p53.

Molecular and cellular biology - 1 Oct 2001

Sadot E, Geiger B, Oren M, Ben-Ze'ev A

Abstract excerpt

beta-Catenin is a cytoplasmic protein that participates in the assembly of cell-cell adherens junctions by binding cadherins to the actin cytoskeleton. In addition, it is a key component of the Wnt signaling pathway. Activation of this pathway triggers the accumulation of beta-catenin in the nucleus, where it activates the transcription of target genes. Abnormal accumulation of beta-catenin is characteristic of...

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Identifiers

PMID: 11564862
DOI: 10.1128/MCB.21.20.6768-6781.2001
PMCID: PMC99855

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