Article
Reduced p53 dosage associated with mammary tumor metastases in C3(1)/TAG transgenic mice.
Molecular carcinogenesis - 1 Oct 1997
Maroulakou I G, Shibata M A, Jorcyk C L, Chen X X, Green J E
Abstract excerpt
Transgenic mice expressing the simian virus 40 large T-antigen (TAG) under the regulatory control of the rat prostatic steroid binding protein C3(1) gene develop mammary carcinomas (in females) and prostate carcinomas (in males). The development of carcinomas occurs several months after the appearance of dysplastic lesions, suggesting that TAG is necessary but insufficient for tumor formation and that other...
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