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Article

Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.

Development (Cambridge, England) - 1 May 2009

Moraes Ricardo C, Chang Hong, Harrington Nikesha, Landua John D, Prigge Jonathan T, Lane Timothy F, Wainwright Brandon J, Hamel Paul A, Lewis Michael T

Abstract excerpt

Systemic hormones and local growth factor-mediated tissue interactions are essential for mammary gland development. Using phenotypic and transplantation analyses of mice carrying the mesenchymal dysplasia (mes) allele of patched 1 (Ptch1(mes)), we found that Ptch1(mes) homozygosity led to either complete failure of gland development, failure of post-pubertal ductal elongation, or delayed growth with ductal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

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Source

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Identifiers

PMID: 19297414
DOI: 10.1242/dev.023994
PMCID: PMC2675781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.PMID 19297414Read ↗

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