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Article

Loss of Nfkb1 leads to early onset aging.

Aging - 1 Nov 2014

Bernal Giovanna M, Wahlstrom Joshua S, Crawley Clayton D, Cahill Kirk E, Pytel Peter, Liang Hua, Kang Shijun, Weichselbaum Ralph R, Yamini Bakhtiar

Abstract excerpt

NF-κB is a major regulator of age-dependent gene expression and the p50/NF-κB1 subunit is an integral modulator of NF-κB signaling. Here, we examined Nfkb1-/- mice to investigate the relationship between this subunit and aging. Although Nfkb1-/- mice appear similar to littermates at six months of age, by 12 months they have a higher incidence of several observable age-related phenotypes. In addition, aged...

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Identifiers

PMID: 25553648
DOI: 10.18632/aging.100702
PMCID: PMC4276787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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