Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2001

Mousavi-Jazi M, Schloss L, Drew W L, Linde A, Miner R C, Harmenberg J, Wahren B, Brytting M

Abstract excerpt

BACKGROUND: Identification of human cytomegalovirus (CMV) genome variation is important for understanding mutations associated with drug resistance. OBJECTIVES: To investigate the CMV resistance to foscarnet (PFA) and ganciclovir (GCV) in patients treated with antiviral drugs and to identify the DNA polymerase (UL54) and phosphotransferase (UL97) gene mutations inducing resistance. STUDY DESIGN: Antiviral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus
Share to Cytomegalovirus Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Drug Resistance, Multiple, Viral

Share to Foscarnet

Share to Ganciclovir

Share to Genes, Viral

Share to Phosphotransferases

Source

Identifiers

PMID: 11595579
DOI: 10.1016/s1386-6532(01)00160-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity.PMID 11595579Read ↗

Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene.Semantic proximity Read ↗

Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy.Semantic proximity Read ↗

The biology of cytomegalovirus drug resistance.Semantic proximity Read ↗

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.Semantic proximity Read ↗

A new locus of foscarnet resistance in the cytomegalovirus UL54 DNA polymerase gene among uncharacterized mutations in recent clinical trials.Semantic proximity Read ↗

Antiviral Drug Resistance of Human CytomegalovirusSemantic proximity Read ↗

Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase.Semantic proximity Read ↗

Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art.Semantic proximity Read ↗

HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil.Semantic proximity Read ↗

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.Semantic proximity Read ↗

A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet.Semantic proximity Read ↗

Drug-resistant cytomegalovirus: clinical implications of specific mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.