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Article

Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase.

Antimicrobial agents and chemotherapy - 24 Mar 2020

Zarrouk Karima, Pham Van Dung, Piret Jocelyne, Shi Rong, Boivin Guy

Abstract excerpt

Herein, we phenotypically and enzymatically characterize the theoretical mutation Q579I in helix K and the already described clinical mutation K805Q in helix P of cytomegalovirus DNA polymerase for susceptibility to foscarnet. Q579I and K805Q recombinant viruses were hypersusceptible to foscarnet (respective mean 50% effective concentrations [EC50] of 0.12- and 0.19-fold that of the wild type). Three-dimensional...

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Source

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Identifiers

PMID: 32015044
DOI: 10.1128/AAC.01910-19
PMCID: PMC7179328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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