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Article

Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet.

Antimicrobial agents and chemotherapy - 17 Jun 2021

Zarrouk Karima, Zhu Xiaojun, Pham Van Dung, Goyette Nathalie, Piret Jocelyne, Shi Rong, Boivin Guy

Abstract excerpt

Amino acid substitutions conferring resistance of herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV) to foscarnet (PFA) are located in the genes UL30 and UL54, respectively, encoding the DNA polymerase (pol). In this study, we analyzed the impact of substitutions located in helix K and region II that are involved in the conformational changes of the DNA pol. Theoretical substitutions were identified...

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Identifiers

PMID: 33875432
DOI: 10.1128/AAC.00390-21
PMCID: PMC8218610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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