Article
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.
The Journal of infectious diseases - 1 Oct 1991
Sullivan V, Coen D M
Abstract excerpt
Investigations of mutants of human cytomegalovirus (CMV) that are resistant to foscarnet could shed light on mechanisms of selective drug action and features of drug resistance that may be clinically important. Preexisting foscarnet-resistant mutants could not be detected in a stock of wild-type...
Topics
- Antiviral Agents
- Cells, Cultured
- Cytomegalovirus
- Drug Resistance, Microbial
- Fibroblasts
- Foscarnet
- Humans
- Mutation
- Neutralization Tests
- Nucleic Acid Hybridization
- Phosphonoacetic Acid
- Serial Passage
