Article
Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2003
Mousavi-Jazi Mehrdad, Schloss Lottie, Wahren Britta, Brytting Maria
Abstract excerpt
BACKGROUND: In vitro selection of viruses with decreased drug susceptibility is a useful tool for mapping drug resistance-associated alterations, evaluating cross-resistance profiles, and elucidating molecular mechanisms of antiviral activity. OBJECTIVES: To provide data on mechanisms of selective drug action and features of drug resistance that may be clinically important. STUDY DESIGN: Foscarnet (PFA) and...
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