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Article

A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet.

Antiviral therapy - 1 Jan 2006

Ducancelle Alexandra, Champier Gaël, Alain Sophie, Petit Françoise, Le Pors Marie-José Sanson, Mazeron Marie-Christine

Abstract excerpt

Foscarnet is currently licensed for the treatment of human cytomegalovirus (HCMV) infection. Mutations proven to confer resistance to foscarnet have mostly been mapped to regions II, III and VI of the HCMV UL54-encoded DNA polymerase. We previously showed that sequential foscarnet-resistant HCMV isolates recovered from a patient with lymphoma had change N495K in region delta-C of the DNA polymerase. To evaluate...

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PMID: 16856628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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