Article
Sugar binding induces an outward facing conformation of LacY.
Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2007
Smirnova Irina, Kasho Vladimir, Choe Jun-Yong, Altenbach Christian, Hubbell Wayne L, Kaback H Ronald
Abstract excerpt
According to x-ray structure, the lactose permease (LacY) is a monomer organized into N- and C-terminal six-helix bundles that form a deep internal cavity open on the cytoplasmic side with a single sugar-binding site at the apex. The periplasmic side of the molecule is closed. During sugar/H(+) symport, a cavity facing the periplasmic side is thought to open with closure of the inward-facing cytoplasmic cavity so...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.