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Article

Single-molecule FRET reveals sugar-induced conformational dynamics in LacY.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007

Majumdar Devdoot S, Smirnova Irina, Kasho Vladimir, Nir Eyal, Kong Xiangxu, Weiss Shimon, Kaback H Ronald

Abstract excerpt

The N- and C-terminal six-helix bundles of lactose permease (LacY) form a large internal cavity open on the cytoplasmic side and closed on the periplasmic side with a single sugar-binding site at the apex of the cavity near the middle of the molecule. During sugar/H(+) symport, an outward-facing cavity is thought to open with closing of the inward-facing cavity so that the sugar-binding site is alternately...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17502603
DOI: 10.1073/pnas.0700969104
PMCID: PMC1937519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-molecule FRET reveals sugar-induced conformational dynamics in LacY.PMID 17502603Read ↗

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