Article
Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses.
Pharmacogenomics - 1 Sept 2007
Hung Chin-Chuan, Jen Tai John, Kao Pi-Ju, Lin Min-Shung, Liou Horng-Huei
Abstract excerpt
OBJECTIVES: The aim of this study was to investigate whether the polymorphisms in the NR1I2 and ABCB1 genes were associated with epilepsy treatment responses. METHODS & RESULTS: NR1I2and ABCB1 polymorphisms were genotyped in 114 drug-resistant epileptic patients, 213 seizure-free patients and 287 normal controls. Highly specific real-time PCR was applied to detect the variants by using TaqMan allelic specific...
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