Article
Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.
Pharmacogenetics and genomics - 1 Nov 2008
Kwan Patrick, Poon Wai Sang, Ng Ho-Keung, Kang David E, Wong Virginia, Ng Ping Wing, Lui Colin H T, Sin Ngai Chuen, Wong Ka S, Baum Larry
Abstract excerpt
OBJECTIVES: Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment is ineffective in 30% of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes. We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium...
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