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Article

Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta.

Biochemistry - 30 Oct 2007

Lu Peng, Rha Geun Bae, Chi Young-In

Abstract excerpt

HNF1beta is an atypical POU transcription factor that participates in a hierarchical network of transcription factors controlling the development and proper function of vital organs such as liver, pancreas, and kidney. Many inheritable mutations on HNF1beta are the monogenic causes of diabetes and several kidney diseases. To elucidate the molecular mechanism of its function and the structural basis of mutations,...

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Identifiers

PMID: 17924661
DOI: 10.1021/bi7010527
PMCID: PMC2367142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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