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Article

Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants.

The Journal of biological chemistry - 1 Apr 2022

Kind Laura, Raasakka Arne, Molnes Janne, Aukrust Ingvild, Bjørkhaug Lise, Njølstad Pål Rasmus, Kursula Petri, Arnesen Thomas

Abstract excerpt

Hepatocyte nuclear factor 1A (HNF-1A) is a transcription factor expressed in several embryonic and adult tissues, modulating the expression of numerous target genes. Pathogenic variants in the HNF1A gene are known to cause maturity-onset diabetes of the young 3 (MODY3 or HNF1A MODY), a disease characterized by dominant inheritance, age of onset before 25 to 35 years of age, and pancreatic β-cell dysfunction. A...

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Identifiers

PMID: 35257744
DOI: 10.1016/j.jbc.2022.101803
PMCID: PMC8988010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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