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Article

Diabetes mutations delineate an atypical POU domain in HNF-1alpha.

Molecular cell - 1 Nov 2002

Chi Young-In, Frantz J Daniel, Oh Byung-Chul, Hansen Lone, Dhe-Paganon Sirano, Shoelson Steven E

Abstract excerpt

Mutations in Hnf-1alpha are the most common Mendelian cause of diabetes mellitus. To elucidate the molecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affinity promoter and solved the structure of the complex. Two identical protein molecules are bound to the promoter. Each contains a homeodomain and a second domain structurally similar to POU-specific domains that was...

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Identifiers

PMID: 12453420
DOI: 10.1016/s1097-2765(02)00704-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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