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Article

Role of transcription factor hepatocyte nuclear factor-1β in polycystic kidney disease.

Cellular signalling - 1 Jul 2020

Shao Annie, Chan Siu Chiu, Igarashi Peter

Abstract excerpt

Hepatocyte nuclear factor-1β (HNF-1β) is a DNA-binding transcription factor that is essential for normal kidney development. Mutations of HNF1B in humans produce cystic kidney diseases, including renal cysts and diabetes, multicystic dysplastic kidneys, glomerulocystic kidney disease, and autosomal dominant tubulointerstitial kidney disease. Expression of HNF1B is reduced in cystic kidneys from humans with ADPKD,...

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Genetic and Kidney Cyst Diseases
Hepatocyte Nuclear Factor 1-beta
Models, Biological
Mutation
Polycystic Kidney Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renal and related cancers

RNA, Untranslated

Signal Transduction

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Identifiers

PMID: 32068086
DOI: 10.1016/j.cellsig.2020.109568
PMCID: PMC7183897

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