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Structural properties of the HNF-1A transactivation domain

16 Oct 2023

Abstract excerpt

Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased risk for type 2 diabetes. While several pancreatic target genes of HNF-1A have been described, a lack of knowledge regarding the structure-function relationships in HNF-1A prohibits a detailed...

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PMID: 37908230
DOI: 10.3389/fmolb.2023.1249939

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