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Chromosome territory reorganization in a human disease with altered DNA methylation

8 Oct 2007

Abstract excerpt

Chromosome territory (CT) organization and chromatin condensation have been linked to gene expression. Although individual genes can be transcribed from inside CTs, some regions that have constitutively high expression or are coordinately activated loop out from CTs and decondense. The relationship between epigenetic marks, such as DNA methylation, and higher-order chromatin structures is largely unexplored....

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PMID: 17923676
DOI: 10.1073/pnas.0702924104

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