Article
Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications.
Human molecular genetics - 1 Apr 2006
De Bonis M L, Cerase A, Matarazzo M R, Ferraro M, Strazzullo M, Hansen R S, Chiurazzi P, Neri G, D'Esposito M
Abstract excerpt
Maintenance of X-inactivation is achieved through a combination of different repressive mechanisms, thus perpetuating the silencing message through many cell generations. The second human X-Y pseudoautosomal region 2 (PAR2) is a useful model to explore the features and internal relationships of the epigenetic circuits involved in this phenomenon. Recently, we demonstrated that DNA methylation plays an essential...
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