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Expanding studies of chromosome structure and function in the era of T2T genomics.

Human molecular genetics - 1 Oct 2021

Miga Karen H, Sullivan Beth A

Abstract excerpt

The recent accomplishment of a truly complete human genome has afforded a new view of chromosome structure and function that was limited 30 years ago. Here, we discuss the expansion of knowledge from the early cytological studies of the genome to the current high-resolution genomic, epigenetic and functional maps that have been achieved by recent technology and computational advances. These studies have revealed...

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Identifiers

PMID: 34302168
DOI: 10.1093/hmg/ddab214
PMCID: PMC8631062

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