Article
Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.
Genomics - 1 Dec 2007
Tanaka Shigekazu, Miura Ikuo, Yoshiki Atsushi, Kato Yoriko, Yokoyama Haruka, Shinogi Akiko, Masuya Hiroshi, Wakana Shigeharu, Tamura Masaru, Shiroishi Toshihiko
Abstract excerpt
Two classical mouse hair coat mutations, Rex (Re) and Rex wavy coat (Re(wc)), are linked to the type I inner root sheath (IRS) keratin genes of chromosome 11. An N-ethyl-N-nitrosourea-induced mutation, M100573, also maps close to the type I IRS keratin genes. In this study, we demonstrate that Re and M100573 mice bear mutations in the type I IRS gene Krt25; Re(wc) mice bear an additional mutation in the type I...
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