Article
Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency.
The Journal of investigative dermatology - 1 Oct 2003
Peters T, Sedlmeier R, Büssow H, Runkel F, Lüers G H, Korthaus D, Fuchs H, Hrabé de Angelis M, Stumm G, Russ A P, Porter R M, Augustin M, Franz T
Abstract excerpt
Reduced coat 3 (Rco3) is a new spontaneous autosomal recessive mutation with defects in hair structure and progressive alopecia. Here we describe chromosomal mapping and molecular identification of the Rco3 mutation. The murine Rco3 locus maps to a 2-Mb interval on chromosome 15 encompassing the keratin type II gene cluster. Recently, mK6irs1 was described as a type II keratin expressed in Henle's and Huxley's...
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