Article
A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation.
Genetics - 1 Oct 2003
Kikkawa Yoshiaki, Oyama Ayumi, Ishii Rie, Miura Ikuo, Amano Takashi, Ishii Yoshiyuki, Yoshikawa Yasuhiro, Masuya Hiroshi, Wakana Shigeharu, Shiroishi Toshihiko, Taya Choji, Yonekawa Hiromichi
Abstract excerpt
A new mutation has arisen in a colony of mice transgenic for human alpha-galactosidase. The mutation is independent of the transgenic insertion, autosomal dominant, and morphologically very similar to the classical wavy coat mutation, caracul (Ca), on chromosome 15. Therefore, we designated this locus the caracul Rinshoken (Ca(Rin)). Applying a positional cloning approach, we identified the mK6irs1/Krt2-6g gene...
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