Article
A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2009
Baek In Cheol, Kim Jeong Ki, Cho Kyu-Hyuk, Cha Dal-Sun, Cho Jae-Woo, Park Jong Keun, Song Chang-Woo, Yoon Sungjoo Kim
Abstract excerpt
Hairpoor mice (Hr(Hp)) were derived through N-ethyl-N-nitrosourea (ENU) mutagenesis. These mice display sparse and short hair in the Hr(Hp)/+ heterozygous state and complete baldness in the Hr(Hp)/Hr(Hp) homozygous state. This phenotype was irreversible and was inherited in an autosomal semidominant manner. Hair follicles (HFs) of Hr(Hp)/+ mice underwent normal cycling and appeared normal, although smaller than...
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