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Article

[Association between metabolic enzyme genotype of azathioprine and drug tolerance in patients with rheumatic diseases].

Zhonghua yi xue za zhi - 3 Jul 2007

Zhan Zhong-ping, Liang Liu-qin, Yang Xiu-yan, Wang Yi-xi, Huang Min, Li Hao

Abstract excerpt

OBJECTIVE: To discuss the relationship between the genotype of thiopurine methyltransferase (TPMT) and azathioprine tolerance in the patients with rheumatic diseases. METHODS: Four common mutation alleles of TPMT in 200 patients with rheumatic diseases [TPMT*2 (G238C), TPMT*3A (A719G/G460A), TPMT*3B (G460A), TPMT*3C (A719G)] were detected by allele specific polymerase chain reaction (AS-PCR) and polymerase chain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17919375

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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