Article
Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese.
Internal medicine (Tokyo, Japan) - 1 Dec 1999
Ishioka S, Hiyama K, Sato H, Yamanishi Y, McLeod H L, Kumagai K, Maeda H, Yamakido M
Abstract excerpt
OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including Azathioprine (AZA). It has been reported that the level of AZA toxicity is dependent on the TPMT genotypes in Caucasian individuals; we thus investigated this relationship in Japanese. METHODS: The TPMT genotype was determined using...
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