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Article

Activity of artificial mutant variants of human growth hormone deficient in a disulfide bond between Cys53 and Cys165.

Chemical & pharmaceutical bulletin - 1 Jan 1991

Uchida E, Uemura H, Tanaka T, Nishikawa S, Uesugi S, Tanaka A, Morikawa M, Hayakawa T, Ikehara M

Abstract excerpt

In order to understand the role of Cys53 and Cys165 of human growth hormone (hGH) in receptor-binding and biological activity, artificial mutant variants of hGH were prepared in Escherichia coli by in vitro mutagenesis. Variants of hGH were constructed by replacement of Cys165 with Ala ([Ala165]hGH) or Ser ([Ser165]hGH), by replacement of Cys53 with Ala ([Ala53]hGH), by replacement of Cys53 and Cys165 with Ala...

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Identifiers

PMID: 2049799
DOI: 10.1248/cpb.39.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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