Article
Induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation by dendritic cell pulsing with purified and optimized myeloma cell lysates.
Leukemia & lymphoma - 1 Oct 2007
Lee Je-Jung, Choi Bo-Hwa, Kang Hyun-Kyu, Park Myong-Suk, Park Jung-Sun, Kim Sang-Ki, Pham Thanh-Nhan Nguyen, Cho Duck, Nam Jong-Hee, Kim Young-Jin, Rhee Joon-Haeng, Yang Deok-Hwan, Kim Yeo-Kyeoung, Kim Hyeoung-Joon, Chung Ik-Joo
Abstract excerpt
We investigated the possibility of immunotherapy for multiple myeloma (MM) using myeloma-specific cytotoxic T lymphocytes (CTLs) that were stimulated in vitro by dendritic cells (DCs) pulsing with purified and optimized myeloma lysates. CD14(+) cells were cultured in the presence of GM-CSF and IL-4. On day 6, the immature DCs were pulsed with the purified myeloma cell lysates, and then maturation of the DCs was...
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