Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Dembic Z, Schenck K, Bogen B

Abstract excerpt

Multiple myelomas produce tumor-specific antigen (TSA) in the form of idiotype (Id) on monoclonal Ig. CD4(+) T cells can recognize Id-peptide on MHC class II molecules and protect against challenges with MOPC315 cells, which are, as common for myelomas, class II-negative. The present study explains these previous results by demonstrating that Id can be transferred from myeloma cells to antigen-presenting cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Immunoglobulin Idiotypes

Share to Multiple Myeloma

Share to Neoplasm Transplantation

Share to Receptors, Antigen, T-Cell

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 10706628
DOI: 10.1073/pnas.050579897
PMCID: PMC15992

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.PMID 10706628Read ↗

Successful cross-presentation of allogeneic myeloma cells by autologous alpha-type 1-polarized dendritic cells as an effective tumor antigen in myeloma patients with matched monoclonal immunoglobulins.Semantic proximity Read ↗

Efficient presentation of tumor idiotype to autologous T cells by CD83(+) dendritic cells derived from highly purified circulating CD14(+) monocytes in multiple myeloma patients.Semantic proximity Read ↗

Induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation by dendritic cell pulsing with purified and optimized myeloma cell lysates.Semantic proximity Read ↗

Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent.Semantic proximity Read ↗

Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma.Semantic proximity Read ↗

T-cell-epitope mapping of the idiotypic monoclonal IgG heavy and light chains in multiple myeloma.Semantic proximity Read ↗

Dendritic Cells in the Context of Human Tumors: Biology and Experimental ToolsSemantic proximity Read ↗

Enhancement of clonogenicity of human multiple myeloma by dendritic cells.Semantic proximity Read ↗

Long-term effects of idiotype vaccination on the specific T-cell response in peripheral blood and bone marrow of multiple myeloma patients.Semantic proximity Read ↗

The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapySemantic proximity Read ↗

Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma.Semantic proximity Read ↗

Impaired functionality and phenotypic profile of dendritic cells from patients with multiple myeloma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.