Article
Induction of leukemic-cell-specific cytotoxic T lymphocytes by autologous monocyte-derived dendritic cells presenting leukemic cell antigens.
Journal of clinical apheresis - 1 Oct 2006
Lee J-J, Park M-S, Park J-S, Kang H-K, Kim S-K, Nguyen Pham T-N, Zhu X-W, Cho D, Nam J-H, Kim Y-J, Rhee J-H, Chung I-J, Kim H-J
Abstract excerpt
Leukemic-dendritic cells (leukemic-DCs) have certain limitations, which include difficult generation in 30-40% of patients, and low levels of expression of several key molecules. Therefore, an alternative approach using monocyte-derived DCs pulsed with tumor antigens is required. We investigated the possibility of immunotherapy for AML using leukemic-cell-specific cytotoxic T lymphocytes that were stimulated in...
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