Article
[Molecular pharmacologic approaches to functional analysis of new biological target molecules for drug discovery].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Oct 2007
Baba Akemichi
Abstract excerpt
This review focuses on two pharmacologic approaches to the functional evaluation of new target molecules for drug discovery. One is the development of a novel specific antagonist of the Na(+)-Ca(++) exchanger (NCX) SEA0400. The other is a comprehensive analysis of the functions of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide ligand for G protein-coupled receptors. NCX is the one of...
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