Article

Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small Molecule Positive Allosteric Modulator SPAM1 of PAC1-R for the Treatment of D-gal-Induced Aging Mice

2024-03-05

Abstract excerpt

Pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1-R) has a higher affinity for pituitary adenylate cyclase- activating polypeptide (PACAP) than for vasoactive intestinal peptide (VIP). PACAP exerts its neuroprotective effects through PAC1-R. PAC1-R has become a target for drug development, and we targeted PAC1-R to screen small positive allosteric modulator 1 (SPAM1). SPAM1 has a neuroprotective...

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Literature Corpus work: 4ff9b7b0-897c-5a4d-9341-5a572322891d
DOI: 10.20944/preprints202403.0217.v1

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Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small Molecule Positive Allosteric Modulator SPAM1 of PAC1-R for the Treatment of D-gal-Induced Aging MiceDOI 10.20944/preprints202403.0217.v1Read

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