Article
Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations.
Clinical immunology (Orlando, Fla.) - 1 Dec 2007
Fuchizawa Tatsuya, Adachi Yuichi, Ito Yasunori, Higashiyama Hiroyuki, Kanegane Hirokazu, Futatani Takeshi, Kobayashi Ichiro, Kamachi Yoshiro, Sakamoto Tatsuo, Tsuge Ikuya, Tanaka Hiroshi, Banham Alison H, Ochs Hans D, Miyawaki Toshio
Abstract excerpt
FOXP3 is required for the generation and function of CD4(+)CD25(+) regulatory T (Treg) cells. To elucidate the biological role of Treg cells, we used a monoclonal anti-FOXP3 antibody to examine the frequencies of Treg cells during child development. The percentages of CD4(+)CD25(+)FOXP3(+) T cells were constant shortly from after birth through adulthood. CD4(+)CD25(+)FOXP3(+) T cells in cord blood showed the...
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