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Article

A highly conserved tRNA modification contributes to C. albicans filamentation and virulence

8 Apr 2024

Abstract excerpt

ABSTRACT tRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad range of phenotypes in baker’s yeast. Very little is known about the function of tRNA modifications in host-pathogen interactions, where rapidly changing environments...

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PMID: 38587411
DOI: 10.1128/spectrum.04255-22

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