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Article

The search for gamma-secretase and development of inhibitors.

Current medicinal chemistry - 1 Jun 2002

Tsai Jui-Yi, Wolfe Michael S, Xia Weiming

Abstract excerpt

A considerable body of evidence has accumulated in recent years implicating the beta-amyloid protein (Abeta) in the etiology of Alzheimer s disease (AD). The highly hydrophobic Abeta can nucleate and form neurotoxic fibrils that are the principal components of the cerebral plaques characteristic of AD. Abeta is formed from the amyloid-beta precursor protein (APP) through two protease activities. First,...

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Source

Identifiers

PMID: 12052174
DOI: 10.2174/0929867023370185

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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