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Article

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

1 Jan 2012

Abstract excerpt

The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD)-formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline-are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-Takahara et al., 2005). Since γ-secretase is critical for Aβ production, many in the biopharmaceutical community focused...

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PMID: 23320246
DOI: 10.1155/2012/210756

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