Article
Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.
American journal of physiology. Renal physiology - 1 Dec 2007
Xu Hongshi, Tian Wei, Fu Yi, Oyama Terry T, Anderson Sharon, Cohen David M
Abstract excerpt
The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1. TRPV1 mediates aspects of nociception and neurogenic inflammation; however, new roles are emerging in sensation of both luminal stretch and systemic tonicity. Although at least six nonsynonymous polymorphisms in the human TRPV1 gene have been identified, there has been no systematic...
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