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TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss

15 Jul 2020

Abstract excerpt

in postimplantation mouse TSPCs impairs their self-renewal, leading to embryonic lethality before embryonic day 9.0, a developmental stage equivalent to the first trimester of human gestation. Both TEAD4 and its cofactor, yes-associated protein 1 (YAP1), are specifically expressed in cytotrophoblast (CTB) progenitors of a first-trimester human placenta. We also show that a subset of unexplained recurrent...

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PMID: 32669432
DOI: 10.1073/pnas.2002449117

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