Article
Mutations and differential expression of the ras family genes in human nasal polyposis.
International journal of oncology - 1 Nov 2007
Zaravinos Apostolos, Bizakis John, Soufla Giannoula, Sourvinos George, Spandidos Demetrios A
Abstract excerpt
Although it is well established that ras genes contribute to tumourigenesis either through the accumulation of mutations or by aberrant expression in a wide range of human cancers, little is known regarding their involvement in human nasal polyps (NPs). In the present study, the occurrence of mutations in codons 11 and 12 of the ras family genes was examined by PCR/RFLP and direct sequencing in 23 human NPs and...
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