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Article

Molecular alterations in MAPK/ERK, β-Catenin/Wnt, and PI3K/mTOR pathways in adenomatoid odontogenic tumor.

Journal of applied oral science : revista FOB - 1 Jan 2026

Pankam Jintana, Lapthanasupkul Puangwan, Kitkumthorn Nakarin, Khovidhunkit Siribang-On Piboonniyom

Abstract excerpt

BACKGROUND: Previous studies have suggested that tumorigenesis of adenomatoid odontogenic tumor (AOT) may involve the activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. However, research on other oncogenic signaling pathways in AOT remains limited. OBJECTIVE: This study aimed to investigate gene mutations (Kirsten rat sarcoma viral oncogene homolog (KRAS),...

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Identifiers

PMID: 42339980
DOI: 10.1590/1678-7765-2026-0073
PMCID: PMC13290206

Genes

KRAS
PIK3CA
CTNNB1

Variants

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Related research

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Molecular alterations in MAPK/ERK, β-Catenin/Wnt, and PI3K/mTOR pathways in adenomatoid odontogenic tumor.PMID 42339980Read ↗

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