Article
Chronic rhinosinusitis with nasal polyps does not harbor KRAS, BRAF, and EGFR mutations.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 May 2023
da Silva Vieira Tamara, Guimarães Letícia Martins, Diniz Marina Gonçalves, Gomes-Fernandes Bianca, Anselmo-Lima Wilma Terezinha, Tamashiro Edwin, Bastos-Rodrigues Luciana, De Marco Luiz, Gomez Ricardo Santiago, Valera Fabiana Cardoso Pereira, Gomes Carolina Cavalieri
Abstract excerpt
BACKGROUND: Chronic rhinosinusitis is a chronic inflammation of the nasal mucosa and nasal polyps are present in ~25%-30% of cases (chronic rhinosinusitis with nasal polyps [CRSwNP]). CRSwNP is associated with significant morbidity and decreased quality of life, making it clinically important. Inflammation leads to DNA damage and DNA mutations occur in some inflammatory diseases. Notably, mutations in KRAS, BRAF,...
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